Mechanistic basis of using body size and maturation to predict clearance in humans
BJ Anderson, NHG Holford - Drug metabolism and pharmacokinetics, 2009 - Elsevier
Growth and development are two major aspects of children not readily apparent in adults.
Clearance in the paediatric population should be investigated using models that describe
size, maturation and organ function influences. Size is the primary covariate and although
lean body weight is argued as a better measure than total body weight, the use of different
fractions of fat mass to explain how pharmacokinetic parameters vary with body composition
has been proposed. Allometric scaling using an empiric power exponent of 3/4 is superior to …
Clearance in the paediatric population should be investigated using models that describe
size, maturation and organ function influences. Size is the primary covariate and although
lean body weight is argued as a better measure than total body weight, the use of different
fractions of fat mass to explain how pharmacokinetic parameters vary with body composition
has been proposed. Allometric scaling using an empiric power exponent of 3/4 is superior to …