Naloxone reversal of morphine-and morphine-6-glucuronide-induced respiratory depression in healthy volunteers: a mechanism-based pharmacokinetic …
E Olofsen, E van Dorp, L Teppema, L Aarts… - The Journal of the …, 2010 - pubs.asahq.org
Background Opioid-induced respiratory depression is antagonized effectively by the
competitive opioid receptor antagonist naloxone. However, to fully understand the complex
opioid agonist-antagonist interaction, the effects of various naloxone doses on morphine
and morphine-6-glucuronide (M6G)-induced respiratory depression were studied in healthy
volunteers. Methods Twenty-four subjects received 0.15 mg/kg morphine intravenously at t=
0 followed by placebo, 200 or 400 microg naloxone at t= 30 min. Thirty-two subjects …
competitive opioid receptor antagonist naloxone. However, to fully understand the complex
opioid agonist-antagonist interaction, the effects of various naloxone doses on morphine
and morphine-6-glucuronide (M6G)-induced respiratory depression were studied in healthy
volunteers. Methods Twenty-four subjects received 0.15 mg/kg morphine intravenously at t=
0 followed by placebo, 200 or 400 microg naloxone at t= 30 min. Thirty-two subjects …