[HTML][HTML] MAPK signaling is involved in camptothecin-induced cell death

S Lee, HS Lee, M Baek, DY Lee, YJ Bang, HN Cho… - Molecules and cells, 2002 - Elsevier
Camptothecin, a topoisomerase I inhibitor, is a wellknown anticancer drug. However, its
mechanism has not been well studied in human gastric cancer cell lines. Camptothecin
induced apoptotic cell death in human gastric cancer cell line AGS. Z-VAD-fmk, pancaspase
inhibitor, blocked apoptotic phenotypes induced by camptothecin suggesting that caspases
are involved in camptothecin-induced cell death. An inhibitor of caspase-6 or-8 or-9 did not
prevent cell death by camptothecin. Various protease inhibitors failed to prevent …