[HTML][HTML] Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1-and Sp3-dependent activation of two proximal GC-rich …
G Schäfer, T Cramer, G Suske, W Kemmner… - Journal of Biological …, 2003 - ASBMB
Enhanced VEGF-A (vascular endothelial growthfactor A) gene expression is associated with
increased tumor growth and metastatic spread of solid malignancies including gastric
cancer. Oxidative stress has been linked to tumor-associated neoangiogenesis; underlying
mechanisms, however, remained poorly understood. Therefore, we studied the effect of
oxidative stress on VEGF-A gene expression in gastric cancer cells. Oxidative stress
generated by H 2 O 2 application potently stimulated VEGF-A protein and mRNA levels as …
increased tumor growth and metastatic spread of solid malignancies including gastric
cancer. Oxidative stress has been linked to tumor-associated neoangiogenesis; underlying
mechanisms, however, remained poorly understood. Therefore, we studied the effect of
oxidative stress on VEGF-A gene expression in gastric cancer cells. Oxidative stress
generated by H 2 O 2 application potently stimulated VEGF-A protein and mRNA levels as …