[HTML][HTML] Nonhuman primate allogeneic hematopoietic stem cell transplantation by intraosseus vs intravenous injection: Engraftment, donor cell distribution, and …
Q Feng, PKH Chow, F Frassoni, CML Phua… - Experimental …, 2008 - Elsevier
OBJECTIVE: The traditional intravenous (IV) route of administration for hematopoietic stem
cell transplantation (HSCT) may result in inefficient placement of donor cells, possibly
contributing to suboptimal engraftment and higher risk of graft-vs-host reactions. In order to
perform detailed studies of engraftment and donor cell distribution in an animal model with
anatomical similarity to man, we performed the first direct homing/engraftment efficiency
comparison between intraosseus (IO) and IV HSCT in allogeneic nonhuman primate animal …
cell transplantation (HSCT) may result in inefficient placement of donor cells, possibly
contributing to suboptimal engraftment and higher risk of graft-vs-host reactions. In order to
perform detailed studies of engraftment and donor cell distribution in an animal model with
anatomical similarity to man, we performed the first direct homing/engraftment efficiency
comparison between intraosseus (IO) and IV HSCT in allogeneic nonhuman primate animal …