OBJECTIVE: Despite enormous advancements in our comprehension of molecular
mechanisms governing hematopoietic stem cells (HSCs) engraftment in the bone marrow,
current clinical protocols of intravenous (IV) transplantation suffer from a relatively low
seeding efficiency. To solve this problem, intrabone (IB) injection of HSCs has been
proposed. However, the mechanisms underlying the benefit provided by this procedure
remain unknown. This study aims to evaluate the effect of IB on HSCs trafficking and homing …