E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial

DC Angus, MC Birmingham, RA Balk, PJ Scannon… - Jama, 2000 - jamanetwork.com
ContextKnowledge and understanding of gram-negative sepsis have grown over the past 20
years, but the ability to treat severe sepsis successfully has not. ObjectiveTo assess the
efficacy and safety of E5 in the treatment of patients with severe gram-negative sepsis.
DesignA multicenter, double-blind, randomized, placebo-controlled trial conducted at 136
US medical centers from April 1993 to April 1997, designed with 90% power to detect a 25%
relative risk reduction, incorporating 2 planned interim analyses. SettingIntensive care units …