[HTML][HTML] The amount of immature glial cells in organotypic brain slices determines the susceptibility to murine cytomegalovirus infection
H Kawasaki, I Kosugi, Y Arai, Y Tsutsui - Laboratory investigation, 2002 - Elsevier
Cytomegalovirus (CMV) is the most common infectious cause of congenital anomalies of the
brain and also causes brain damage in immunocompromised individuals. We investigated
the effects of murine cytomegalovirus (MCMV) infection on the developing mouse brain in
terms of susceptible cells and age-related resistance to MCMV in brain slice cultures. Brain
slices from BALB/c mice at different developmental stages were infected with recombinant
MCMV in which the lacZ gene was inserted into a late gene. The subventricular zone and …
brain and also causes brain damage in immunocompromised individuals. We investigated
the effects of murine cytomegalovirus (MCMV) infection on the developing mouse brain in
terms of susceptible cells and age-related resistance to MCMV in brain slice cultures. Brain
slices from BALB/c mice at different developmental stages were infected with recombinant
MCMV in which the lacZ gene was inserted into a late gene. The subventricular zone and …