The role of receptor for advanced glycation endproducts (RAGE) in infection
MAD van Zoelen, A Achouiti, T van der Poll - Annual update in intensive …, 2011 - Springer
MAD van Zoelen, A Achouiti, T van der Poll
Annual update in intensive care and emergency medicine 2011, 2011•SpringerDuring evolution, multicellular organisms have developed an impressive arsenal of defense
and repair mechanisms to counteract threats such as infection and trauma. Such an
inflammatory response begins with the detection of the potential life-threatening event by
recognizing so-called danger signals. These signal molecules have been classically divided
into: i) Exogenous, pathogen-associated molecular patterns (PAMPs)[1], which are
conserved motifs on pathogens that are not found in higher eukaryocytes; and ii) …
and repair mechanisms to counteract threats such as infection and trauma. Such an
inflammatory response begins with the detection of the potential life-threatening event by
recognizing so-called danger signals. These signal molecules have been classically divided
into: i) Exogenous, pathogen-associated molecular patterns (PAMPs)[1], which are
conserved motifs on pathogens that are not found in higher eukaryocytes; and ii) …
Abstract
During evolution, multicellular organisms have developed an impressive arsenal of defense and repair mechanisms to counteract threats such as infection and trauma. Such an inflammatory response begins with the detection of the potential life-threatening event by recognizing so-called danger signals. These signal molecules have been classically divided into: i) Exogenous, pathogen-associated molecular patterns (PAMPs) [1], which are conserved motifs on pathogens that are not found in higher eukaryocytes; and ii) endogenous innate danger molecules, also named damage-associated molecular patterns (DAMPs) or alarmins, which are structurally diverse proteins rapidly released by the host itself during infection or (sterile) tissue damage [2].
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