Obesity induces pro-inflammatory B cells and impairs B cell function in old mice
D Frasca, A Diaz, M Romero, T Vazquez… - Mechanisms of ageing …, 2017 - Elsevier
We analyzed B cells infiltrating the Visceral Adipose Tissue (VAT) of young and old mice to
identify contributors to the phenotypic and functional changes observed in aged B cells. We
found higher percentages of pro-inflammatory (age-associated B cells, ABC) and less
Follicular (FO) B cells in VAT as compared to spleen. VAT B cells express higher pro-
adipogenic and inflammatory markers, including NF-kB, as compared to splenic B cells, and
also secrete IgG2c antibodies, some of which have been shown to be autoimmune in other …
identify contributors to the phenotypic and functional changes observed in aged B cells. We
found higher percentages of pro-inflammatory (age-associated B cells, ABC) and less
Follicular (FO) B cells in VAT as compared to spleen. VAT B cells express higher pro-
adipogenic and inflammatory markers, including NF-kB, as compared to splenic B cells, and
also secrete IgG2c antibodies, some of which have been shown to be autoimmune in other …