B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor–derived signals

BF Loder, B Mutschler, RJ Ray, CJ Paige… - The Journal of …, 1999 - rupress.org
BF Loder, B Mutschler, RJ Ray, CJ Paige, P Sideras, R Torres, MC Lamers, R Carsetti
The Journal of experimental medicine, 1999rupress.org
Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and
thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive
from short-lived precursors generated in the bone marrow. We show that selection into the
mature pool is an active process and takes place in the spleen. Two populations of splenic B
cells were identified as precursors for mature B cells. Transitional B cells of type 1 (T1) are
recent immigrants from the bone marrow. They develop into the transitional B cells of type 2 …
Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive from short-lived precursors generated in the bone marrow. We show that selection into the mature pool is an active process and takes place in the spleen. Two populations of splenic B cells were identified as precursors for mature B cells. Transitional B cells of type 1 (T1) are recent immigrants from the bone marrow. They develop into the transitional B cells of type 2 (T2), which are cycling and found exclusively in the primary follicles of the spleen. Mature B cells can be generated from T1 or T2 B cells.
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