Overexpression of collagenase (MMP-1) and stromelysin (MMP-3) by pterygium head fibroblasts
DQ Li, SB Lee, Z Gunja-Smith, Y Liu… - Archives of …, 2001 - jamanetwork.com
Background The balance between matrix metalloproteinases (MMPs) and the tissue
inhibitors of metalloproteinases (TIMPs) determines the extent of connective tissue
degradation and remodeling. Objective To determine whether pterygium, characterized by
fibrovascular invasion into the cornea, may in part be mediated by an increased activity of
MMPs. Materials and Methods Expression of transcripts and proteins of MMPs, TIMPs, and
urokinase plasminogen activator (uPA) by cultured human pterygium head, body, and …
inhibitors of metalloproteinases (TIMPs) determines the extent of connective tissue
degradation and remodeling. Objective To determine whether pterygium, characterized by
fibrovascular invasion into the cornea, may in part be mediated by an increased activity of
MMPs. Materials and Methods Expression of transcripts and proteins of MMPs, TIMPs, and
urokinase plasminogen activator (uPA) by cultured human pterygium head, body, and …