ANO1 regulates cardiac fibrosis via ATI-mediated MAPK pathway
X Tian, C Sun, X Wang, K Ma, Y Chang, Z Guo, J Si - Cell Calcium, 2020 - Elsevier
Cardiac fibrosis is associated with most of heart diseases, but its molecular mechanism
remains unclear. Anoctamin-1 (ANO1), a calcium-activated chloride channels (CaCCs)
protein, plays a critical role in various pathophysiological processes. In the current study, we
identified ANO1 expression in myocardial infarction (MI) model of rat and verified the role of
ANO1 in cardiac fibrosis using transcriptomics combined with RNAi assays. we found that
ANO1 expression was increased during the first two weeks, and decreased in the third week …
remains unclear. Anoctamin-1 (ANO1), a calcium-activated chloride channels (CaCCs)
protein, plays a critical role in various pathophysiological processes. In the current study, we
identified ANO1 expression in myocardial infarction (MI) model of rat and verified the role of
ANO1 in cardiac fibrosis using transcriptomics combined with RNAi assays. we found that
ANO1 expression was increased during the first two weeks, and decreased in the third week …
