[HTML][HTML] Mycophenolic acid-mediated suppression of human CD4+ T cells: more than mere guanine nucleotide deprivation
X He, RL Smeets, HJPM Koenen, PM Vink… - American Journal of …, 2011 - Elsevier
Mycophenolic acid is the active ingredient of the immunosuppressant mycophenolate mofetil
that is widely used in transplantation medicine and autoimmunity. Mycophenolic acid inhibits
inosine monophosphate dehydrogenase, an enzyme involved in biosynthesis of guanine
nucleotides required for lymphocyte clonal expansion. Here, we present novel insights into
the mechanisms underlying mycophenolic acid-mediated suppression of human CD4+ T
cells. Upon CD3/CD28 stimulation, mycophenolic acid inhibited T cell IL-17, IFN-γ and TNF …
that is widely used in transplantation medicine and autoimmunity. Mycophenolic acid inhibits
inosine monophosphate dehydrogenase, an enzyme involved in biosynthesis of guanine
nucleotides required for lymphocyte clonal expansion. Here, we present novel insights into
the mechanisms underlying mycophenolic acid-mediated suppression of human CD4+ T
cells. Upon CD3/CD28 stimulation, mycophenolic acid inhibited T cell IL-17, IFN-γ and TNF …