[HTML][HTML] Absolute quantification of donor-derived cell-free DNA as a marker of rejection and graft injury in kidney transplantation: Results from a prospective …
M Oellerich, M Shipkova, T Asendorf, PD Walson… - American journal of …, 2019 - Elsevier
Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive biomarker for comprehensive
monitoring of allograft injury and rejection in kidney transplantation (KTx). dd-cfDNA
quantification of copies/mL plasma (dd-cfDNA [cp/mL]) was compared to dd-cfDNA fraction
(dd-cfDNA [%]) at prespecified visits in 189 patients over 1 year post KTx. In patients (N= 15,
n= 22 samples) with biopsy-proven rejection (BPR), median dd-cfDNA (cp/mL) was 3.3-fold
and median dd-cfDNA (%) 2.0-fold higher (82 cp/mL; 0.57%, respectively) than medians in …
monitoring of allograft injury and rejection in kidney transplantation (KTx). dd-cfDNA
quantification of copies/mL plasma (dd-cfDNA [cp/mL]) was compared to dd-cfDNA fraction
(dd-cfDNA [%]) at prespecified visits in 189 patients over 1 year post KTx. In patients (N= 15,
n= 22 samples) with biopsy-proven rejection (BPR), median dd-cfDNA (cp/mL) was 3.3-fold
and median dd-cfDNA (%) 2.0-fold higher (82 cp/mL; 0.57%, respectively) than medians in …