MicroRNAs regulate renal tubule maturation through modulation of Pkd1
MicroRNAs (miRNAs) contribute to the regulation of early kidney development, but their role
during later stages of renal tubule maturation is not well understood. Here, we found that
ablation of the miRNA-processing enzyme Dicer from maturing renal tubules produces
tubular and glomerular cysts in mice. Inactivation of Dicer is associated with downregulation
of miR-200, a kidney-enriched miRNA family, and upregulation of the polycystic kidney
disease gene Pkd1. Inhibition of miR-200 in cultured renal epithelial cells disrupted …
during later stages of renal tubule maturation is not well understood. Here, we found that
ablation of the miRNA-processing enzyme Dicer from maturing renal tubules produces
tubular and glomerular cysts in mice. Inactivation of Dicer is associated with downregulation
of miR-200, a kidney-enriched miRNA family, and upregulation of the polycystic kidney
disease gene Pkd1. Inhibition of miR-200 in cultured renal epithelial cells disrupted …