Juxtaglomerular cells are highly specialized myoepithelioid granulated cells located in the
glomerular afferent arterioles. These cells synthesize and release renin, which distinguishes
them from other cells. How these cells maintain their identity, restricted localization, and fate
is unknown and is fundamental to the control of BP and homeostasis of fluid and
electrolytes. Because microRNAs may control cell fate via temporal and spatial gene
regulation, we generated mice with a conditional deletion of Dicer, the RNase III …