MicroRNA-17~ 92 is required for nephrogenesis and renal function
AK Marrone, DB Stolz, SI Bastacky… - Journal of the …, 2014 - journals.lww.com
Deletion of all microRNAs (miRNAs) in nephron progenitors leads to premature loss of these
cells, but the roles of specific miRNAs in progenitors have not been identified. Deletions in
the MIR17HG cluster (miR-17~ 92 in mice), detected in a subset of patients with Feingold
syndrome, represent the first miRNA mutations to be associated with a developmental defect
in humans. Although MIR17HG is expressed in the developing kidney, and patients with
Feingold syndrome caused by MYCN mutations have renal anomalies, it remains unclear to …
cells, but the roles of specific miRNAs in progenitors have not been identified. Deletions in
the MIR17HG cluster (miR-17~ 92 in mice), detected in a subset of patients with Feingold
syndrome, represent the first miRNA mutations to be associated with a developmental defect
in humans. Although MIR17HG is expressed in the developing kidney, and patients with
Feingold syndrome caused by MYCN mutations have renal anomalies, it remains unclear to …