[HTML][HTML] Therapeutic advances of miRNAs: A preclinical and clinical update

C Chakraborty, AR Sharma, G Sharma… - Journal of advanced …, 2021 - Elsevier
C Chakraborty, AR Sharma, G Sharma, SS Lee
Journal of advanced research, 2021Elsevier
Background miRNAs, a class of small endogenous RNAs, are one of the essential
biopharmaceuticals which are in commercial spans as next-generation medicine in recent
times. Aim of the Review A snapshot of the current scenario regarding the miRNAs as
biopharmaceuticals have been discussed. Key Scientific Concepts of Review In this work,
biopharmaceutical companies working with miRNAs and the current status of
preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent …
Background
miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times.
Aim of the Review
A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed.
Key Scientific Concepts of Review
In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated.
Elsevier