[HTML][HTML] T-lymphoid differentiation potential measured in vitro is higher in CD34+ CD38−/lo hematopoietic stem cells from umbilical cord blood than from bone marrow …
M De Smedt, G Leclercq, B Vandekerckhove… - …, 2011 - ncbi.nlm.nih.gov
haematologica, 2011•ncbi.nlm.nih.gov
Background Human bone marrow and umbilical cord blood are sources of allogeneic
hematopoietic stem cells for transplantation, which is a life-saving treatment in a variety of
diseases but is burdened by delayed T-cell reconstitution. Observational studies evaluating
T-cell reconstitution in post-transplant recipients suggest that cord blood hematopoietic stem
cells have a more effective capacity for T-cell reconstitution. This study focuses on the
comparison of the capacity of cord blood and bone marrow hematopoietic stem cells to …
hematopoietic stem cells for transplantation, which is a life-saving treatment in a variety of
diseases but is burdened by delayed T-cell reconstitution. Observational studies evaluating
T-cell reconstitution in post-transplant recipients suggest that cord blood hematopoietic stem
cells have a more effective capacity for T-cell reconstitution. This study focuses on the
comparison of the capacity of cord blood and bone marrow hematopoietic stem cells to …
Abstract
Background
Human bone marrow and umbilical cord blood are sources of allogeneic hematopoietic stem cells for transplantation, which is a life-saving treatment in a variety of diseases but is burdened by delayed T-cell reconstitution. Observational studies evaluating T-cell reconstitution in post-transplant recipients suggest that cord blood hematopoietic stem cells have a more effective capacity for T-cell reconstitution. This study focuses on the comparison of the capacity of cord blood and bone marrow hematopoietic stem cells to generate T cells in vitro.
ncbi.nlm.nih.gov