Resident-memory T cells in tissue-restricted immune responses: for better or worse?
K Steinbach, I Vincenti, D Merkler - Frontiers in immunology, 2018 - frontiersin.org
K Steinbach, I Vincenti, D Merkler
Frontiers in immunology, 2018•frontiersin.orgTissue-resident-memory CD8+ T cells (TRM) have been described as a non-circulating
memory T cell subset that persists at sites of previous infection. While TRM in all non-
lymphoid organs probably share a core signature differentiation pathway, certain aspects of
their maintenance and effector functions may vary. It is well-established that TRM provide
long-lived protective immunity through immediate effector function and accelerated
recruitment of circulating immune cells. Besides immune defense against pathogens, other …
memory T cell subset that persists at sites of previous infection. While TRM in all non-
lymphoid organs probably share a core signature differentiation pathway, certain aspects of
their maintenance and effector functions may vary. It is well-established that TRM provide
long-lived protective immunity through immediate effector function and accelerated
recruitment of circulating immune cells. Besides immune defense against pathogens, other …
Tissue-resident-memory CD8+ T cells (TRM) have been described as a non-circulating memory T cell subset that persists at sites of previous infection. While TRM in all non-lymphoid organs probably share a core signature differentiation pathway, certain aspects of their maintenance and effector functions may vary. It is well-established that TRM provide long-lived protective immunity through immediate effector function and accelerated recruitment of circulating immune cells. Besides immune defense against pathogens, other immunological roles of TRM are less well-studied. Likewise, evidence of a putative detrimental role of TRM for inflammatory diseases is only beginning to emerge. In this review, we discuss the protective and harmful role of TRM in organ-specific immunity and immunopathology as well as prospective implications for immunomodulatory therapy.
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