Inherited interleukin 2–inducible T-cell (ITK) kinase deficiency in siblings with epidermodysplasia verruciformis and Hodgkin lymphoma
Clinical Infectious Diseases, 2019•academic.oup.com
Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-
Barr virus (EBV)–lymphoproliferative disorders. We describe a novel association of a
homozygous ITK mutation with β–human papillomavirus (HPV)–positive epidermodysplasia
verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell
responses to oncogenic viruses, including β-HPV and EBV.
Barr virus (EBV)–lymphoproliferative disorders. We describe a novel association of a
homozygous ITK mutation with β–human papillomavirus (HPV)–positive epidermodysplasia
verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell
responses to oncogenic viruses, including β-HPV and EBV.
Abstract
Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)–lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with β–human papillomavirus (HPV)–positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including β-HPV and EBV.
Oxford University Press