Background & Aims Severe forms of alcohol-related liver disease are associated with
increased susceptibility to infections which are associated with poor prognosis. The cellular
and molecular mechanisms responsible for this altered host defense are incompletely
understood. Methods We performed whole blood phenotypic analysis and ex vivo
stimulation with various pathogen-associated molecular patterns (PAMPs). We included 34
patients with alcohol-related cirrhosis (18 of whom had biopsy-proven severe alcoholic …