[HTML][HTML] The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses
K Blaszczyk, H Nowicka, K Kostyrko… - Cytokine & growth factor …, 2016 - Elsevier
In the canonical pathway of IFN-I-mediated signaling, phosphorylation of STAT1 and STAT2
leads to heterodimerization and interaction with IRF9. This complex, also known as IFN-
stimulated gene factor 3 (ISGF3), then translocates into the nucleus and binds the IFN-I-
stimulated response element (ISRE) leading to the activation of transcription of over 300
interferon stimulated genes (ISGs). In addition, STAT1 homodimers [known as γ-activated
factor (GAF)] are formed and translocate to the nucleus, where they target genes containing …
leads to heterodimerization and interaction with IRF9. This complex, also known as IFN-
stimulated gene factor 3 (ISGF3), then translocates into the nucleus and binds the IFN-I-
stimulated response element (ISRE) leading to the activation of transcription of over 300
interferon stimulated genes (ISGs). In addition, STAT1 homodimers [known as γ-activated
factor (GAF)] are formed and translocate to the nucleus, where they target genes containing …
