[HTML][HTML] Megakaryocytes use in vivo podosome‐like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids
A Eckly, C Scandola, A Oprescu, D Michel… - Journal of Thrombosis …, 2020 - Elsevier
Background Blood platelets are anucleate cell fragments that prevent bleeding and
minimize blood vessel injury. They are formed from the cytoplasm of megakaryocytes
located in the bone marrow. For successful platelet production, megakaryocyte fragments
must pass through the sinusoid endothelial barrier by a cell biology process unique to these
giant cells as compared with erythrocytes and leukocytes. Currently, the mechanisms by
which megakaryocytes interact and progress through the endothelial cells are not …
minimize blood vessel injury. They are formed from the cytoplasm of megakaryocytes
located in the bone marrow. For successful platelet production, megakaryocyte fragments
must pass through the sinusoid endothelial barrier by a cell biology process unique to these
giant cells as compared with erythrocytes and leukocytes. Currently, the mechanisms by
which megakaryocytes interact and progress through the endothelial cells are not …
