14-3-3 proteins mediate an essential anti-apoptotic signal
SC Masters, H Fu - Journal of Biological Chemistry, 2001 - jbc.org
The 14-3-3 proteins are a family of highly conserved eukaryotic regulatory molecules that
play important roles in many biological processes including cell cycle control and regulation
of cell death. They are able to carry out these effects through binding and modulating the
activity of a host of signaling proteins. The ability of 14-3-3 to inhibit Bad and other
proapoptotic proteins argues that 14-3-3 can support cell survival. To examine this issue in a
global sense, a specific inhibitor of 14-3-3/ligand interactions, difopein, was used. Difopein …
play important roles in many biological processes including cell cycle control and regulation
of cell death. They are able to carry out these effects through binding and modulating the
activity of a host of signaling proteins. The ability of 14-3-3 to inhibit Bad and other
proapoptotic proteins argues that 14-3-3 can support cell survival. To examine this issue in a
global sense, a specific inhibitor of 14-3-3/ligand interactions, difopein, was used. Difopein …
