[HTML][HTML] Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis
Y Mugabo, M Sadeghi, NN Fang, T Mayor… - Journal of Biological …, 2018 - ASBMB
Adipogenesis involves a complex signaling network requiring strict temporal and spatial
organization of effector molecules. Molecular scaffolds, such as 14-3-3 proteins, facilitate
such organization, and we have previously identified 14-3-3ζ as an essential scaffold in
adipocyte differentiation. The interactome of 14-3-3ζ is large and diverse, and it is possible
that novel adipogenic factors may be present within it, but this possibility has not yet been
tested. Herein, we generated mouse embryonic fibroblasts from mice overexpressing a …
organization of effector molecules. Molecular scaffolds, such as 14-3-3 proteins, facilitate
such organization, and we have previously identified 14-3-3ζ as an essential scaffold in
adipocyte differentiation. The interactome of 14-3-3ζ is large and diverse, and it is possible
that novel adipogenic factors may be present within it, but this possibility has not yet been
tested. Herein, we generated mouse embryonic fibroblasts from mice overexpressing a …