Somatic Mutations of IDH1 and IDH2 in the Leukemic Transformation of Myeloproliferative Neoplasms
A Green, P Beer - New England Journal of Medicine, 2010 - Mass Medical Soc
A Green, P Beer
New England Journal of Medicine, 2010•Mass Medical SocTo the Editor: Somatic mutations affecting the R132 residue of isocitrate dehydrogenase 1
(IDH1) and the homologous IDH2 R172 occur in central nervous system tumors. 1, 2
Recently (in the Sept. 10 issue of the Journal 3), alterations of IDH1 R132 (in exon 2) were
reported in 16 of 188 patients with de novo acute myeloid leukemia, with a strong
association with a normal karyotype; however, mutations of IDH2 R172 (in exon 4) were not
detected. We sequenced exon 2 of the IDH1 gene and exon 4 of the IDH2 gene in patients …
(IDH1) and the homologous IDH2 R172 occur in central nervous system tumors. 1, 2
Recently (in the Sept. 10 issue of the Journal 3), alterations of IDH1 R132 (in exon 2) were
reported in 16 of 188 patients with de novo acute myeloid leukemia, with a strong
association with a normal karyotype; however, mutations of IDH2 R172 (in exon 4) were not
detected. We sequenced exon 2 of the IDH1 gene and exon 4 of the IDH2 gene in patients …
To the Editor: Somatic mutations affecting the R132 residue of isocitrate dehydrogenase 1 (IDH1) and the homologous IDH2 R172 occur in central nervous system tumors.1,2 Recently (in the Sept. 10 issue of the Journal 3), alterations of IDH1 R132 (in exon 2) were reported in 16 of 188 patients with de novo acute myeloid leukemia, with a strong association with a normal karyotype; however, mutations of IDH2 R172 (in exon 4) were not detected. We sequenced exon 2 of the IDH1 gene and exon 4 of the IDH2 gene in patients with leukemia that had evolved from . . .
The New England Journal Of Medicine