[HTML][HTML] Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal …
J Berrout, M Jin, M Mamenko, O Zaika… - Journal of Biological …, 2012 - ASBMB
The TRPV4 Ca 2+-permeable channel is sensitive to mechanical stimuli. In the current study
we have employed immunocytochemical staining in kidney slices and functional
assessments (Ca 2+ imaging) in isolated, split-opened, tubule segments to define TRPV4
sites of expression and flow-dependent function in the collecting duct system. Staining
patterns revealed strong expression of TRPV4 along the entire collecting duct system with
highest levels at the apical (luminal)/subapical region of the principal cells (PCs), the …
we have employed immunocytochemical staining in kidney slices and functional
assessments (Ca 2+ imaging) in isolated, split-opened, tubule segments to define TRPV4
sites of expression and flow-dependent function in the collecting duct system. Staining
patterns revealed strong expression of TRPV4 along the entire collecting duct system with
highest levels at the apical (luminal)/subapical region of the principal cells (PCs), the …