Transient receptor ion channels have emerged as immensely important channels/receptors
in diverse physiological and pathological responses. Of particular interest is the transient
receptor potential channel subfamily V member 4 (TRPV4), which is a polymodal,
nonselective, calcium-permeant cation channel, and is activated by both endogenous and
exogenous stimuli. Both neuronal and nonneuronal cells express functional TRPV4, which
is responsive to a variety of biochemical and biomechanical stimuli. Emerging discoveries …