NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients
S Malhotra, M Sorosina, J Río, S Peroni… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Multiple Sclerosis Journal, 2018•journals.sagepub.com
We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3)
polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple
sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of
665 relapsing-remitting MS patients recruited across 5 centers and classified into
responders and non-responders according to clinical-radiological criteria after 1 year of
IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the …
polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple
sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of
665 relapsing-remitting MS patients recruited across 5 centers and classified into
responders and non-responders according to clinical-radiological criteria after 1 year of
IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the …
We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.
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