New insights into the role of oxidative stress in scleroderma fibrosis
A Gabrielli, S Svegliati, G Moroncini… - The open …, 2012 - pmc.ncbi.nlm.nih.gov
A Gabrielli, S Svegliati, G Moroncini, D Amico
The open rheumatology journal, 2012•pmc.ncbi.nlm.nih.govSystemic sclerosis (Scleroderma–SSc) is a connective tissue disorder of unknown aetiology
characterized by extensive fibrosis of the skin and visceral organs, by vascular abnormalities
and immunological manifestations. Recent evidence suggest that the cellular redox state
may play a significant role in the progression of scleroderma fibrosis. Mechanisms involved
include an autoamplification circuit linking ROS, Ras and ERK 1-2 which in turn amplifies
and maintains the autocrine loop made up by cytokines, growth factors and their cognate …
characterized by extensive fibrosis of the skin and visceral organs, by vascular abnormalities
and immunological manifestations. Recent evidence suggest that the cellular redox state
may play a significant role in the progression of scleroderma fibrosis. Mechanisms involved
include an autoamplification circuit linking ROS, Ras and ERK 1-2 which in turn amplifies
and maintains the autocrine loop made up by cytokines, growth factors and their cognate …
Systemic sclerosis (Scleroderma – SSc) is a connective tissue disorder of unknown aetiology characterized by extensive fibrosis of the skin and visceral organs, by vascular abnormalities and immunological manifestations. Recent evidence suggest that the cellular redox state may play a significant role in the progression of scleroderma fibrosis. Mechanisms involved include an autoamplification circuit linking ROS, Ras and ERK 1-2 which in turn amplifies and maintains the autocrine loop made up by cytokines, growth factors and their cognate receptors. This review summarizes the recent progress on the role of oxidative stress in the pathophysiology of scleroderma and disorders characterised by organ fibrosis
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