[HTML][HTML] PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth
Phosphatases of regenerating liver (PRLs) are markers of cancer and promote tumor
growth. They have been implicated in a variety of biochemical pathways but the
physiologically relevant target of phosphatase activity has eluded 20 years of investigation.
Here, we show that PRL3 catalytic activity is not required in a mouse model of metastasis.
PRL3 binds and inhibits CNNM4, a membrane protein associated with magnesium
transport. Analysis of PRL3 mutants specifically defective in either CNNM-binding or …
growth. They have been implicated in a variety of biochemical pathways but the
physiologically relevant target of phosphatase activity has eluded 20 years of investigation.
Here, we show that PRL3 catalytic activity is not required in a mouse model of metastasis.
PRL3 binds and inhibits CNNM4, a membrane protein associated with magnesium
transport. Analysis of PRL3 mutants specifically defective in either CNNM-binding or …