Decontamination strategies and bloodstream infections with antibiotic-resistant microorganisms in ventilated patients: a randomized clinical trial
BH Wittekamp, NL Plantinga, BS Cooper… - Jama, 2018 - jamanetwork.com
Importance The effects of chlorhexidine (CHX) mouthwash, selective oropharyngeal
decontamination (SOD), and selective digestive tract decontamination (SDD) on patient
outcomes in ICUs with moderate to high levels of antibiotic resistance are unknown.
Objective To determine associations between CHX 2%, SOD, and SDD and the occurrence
of ICU-acquired bloodstream infections with multidrug-resistant gram-negative bacteria
(MDRGNB) and 28-day mortality in ICUs with moderate to high levels of antibiotic …
decontamination (SOD), and selective digestive tract decontamination (SDD) on patient
outcomes in ICUs with moderate to high levels of antibiotic resistance are unknown.
Objective To determine associations between CHX 2%, SOD, and SDD and the occurrence
of ICU-acquired bloodstream infections with multidrug-resistant gram-negative bacteria
(MDRGNB) and 28-day mortality in ICUs with moderate to high levels of antibiotic …