Molecular defects in mastocytosis: KIT and beyond KIT
S Bibi, F Langenfeld… - Immunology and …, 2014 - immunology.theclinics.com
Mast cells (MCs) are multifunctional immune cells derived from hematopoietic stem cell
(HSC) in the bone marrow (BM). Committed BM MC progenitors (MCPs) are released into
the bloodstream, where they have been identified in humans as CD341/KIT1/CD131/FcεRI–
cells. 1 Human MCPs migrate into the peripheral tissues, where they differentiate terminally
into 2 major subtypes: MCtryptase (MCT) and MCtryptase-chymase (MCTC). MCT are found
preferentially in mucosal tissues, whereas MCTC are prominent in serosal tissues. 2, 3 For …
(HSC) in the bone marrow (BM). Committed BM MC progenitors (MCPs) are released into
the bloodstream, where they have been identified in humans as CD341/KIT1/CD131/FcεRI–
cells. 1 Human MCPs migrate into the peripheral tissues, where they differentiate terminally
into 2 major subtypes: MCtryptase (MCT) and MCtryptase-chymase (MCTC). MCT are found
preferentially in mucosal tissues, whereas MCTC are prominent in serosal tissues. 2, 3 For …