Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice
T Naka, T Matsumoto, M Narazaki, M Fujimoto… - Proceedings of the …, 1998 - pnas.org
T Naka, T Matsumoto, M Narazaki, M Fujimoto, Y Morita, Y Ohsawa, H Saito, T Nagasawa…
Proceedings of the National Academy of Sciences, 1998•pnas.orgGrowth, differentiation, and programmed cell death (apoptosis) are mainly controlled by
cytokines. The Janus kinase–signal transducers and activators of transcription (JAK-STAT)
signal pathway is an important component of cytokine signaling. We have previously shown
that STAT3 induces a molecule designated as SSI-1, which inhibits STAT3 functions. To
clarify the physiological roles of SSI-1 in vivo, we generated, here, mice lacking SSI-1. These
SSI-1−/− mice displayed growth retardation and died within 3 weeks after birth. Lymphocytes …
cytokines. The Janus kinase–signal transducers and activators of transcription (JAK-STAT)
signal pathway is an important component of cytokine signaling. We have previously shown
that STAT3 induces a molecule designated as SSI-1, which inhibits STAT3 functions. To
clarify the physiological roles of SSI-1 in vivo, we generated, here, mice lacking SSI-1. These
SSI-1−/− mice displayed growth retardation and died within 3 weeks after birth. Lymphocytes …
Growth, differentiation, and programmed cell death (apoptosis) are mainly controlled by cytokines. The Janus kinase–signal transducers and activators of transcription (JAK-STAT) signal pathway is an important component of cytokine signaling. We have previously shown that STAT3 induces a molecule designated as SSI-1, which inhibits STAT3 functions. To clarify the physiological roles of SSI-1 in vivo, we generated, here, mice lacking SSI-1. These SSI-1−/− mice displayed growth retardation and died within 3 weeks after birth. Lymphocytes in the thymus and spleen of the SSI-1−/− mice exhibited accelerated apoptosis with aging, and their number was 20–25% of that in SSI-1+/+ mice at 10 days of age. However, the differentiation of lymphocytes lacking SSI-1 appeared to be normal. Among various pro- and anti-apoptotic molecules examined, an up-regulation of Bax was found in lymphocytes of the spleen and thymus of SSI-1−/− mice. These findings suggest that SSI-1 prevents apoptosis by inhibiting the expression of Bax.
pnas.org
