[HTML][HTML] Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells
Mutations in the c-kit gene occur in the vast majority of mastocytosis. In adult patients as well
as in the cell line derived from mast cell neoplasms, the mutations occur almost exclusively
at amino acid 816 within the kinase domain of KIT. Among the downstream effectors of KIT
signaling, STAT3 and STAT5 have been shown to be critical for cell proliferation elicited by
the KIT-Asp 816 mutant protein. However, little is known about the mechanisms of activation
of STAT proteins. In this study, we identify and clarify the contribution of various STAT …
as in the cell line derived from mast cell neoplasms, the mutations occur almost exclusively
at amino acid 816 within the kinase domain of KIT. Among the downstream effectors of KIT
signaling, STAT3 and STAT5 have been shown to be critical for cell proliferation elicited by
the KIT-Asp 816 mutant protein. However, little is known about the mechanisms of activation
of STAT proteins. In this study, we identify and clarify the contribution of various STAT …