Mastocytosis is a disorder of increased mast cell proliferation, with both cutaneous and
systemic manifestations. Clinical features of mastocytosis include flushing, pruritus,
abdominal pain, diarrhea, hypotension, syncope, and musculoskeletal pain. These features
are primarily the result of mast cell mediator release and infiltration into skin, gastrointestinal
(GI) tract, liver, spleen, lymph nodes, and bone marrow. The skin is the most common site of
involvement. Cutaneous disease manifestations include urticaria pigmentosa, diffuse …