Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia
AH Cull, D Mahendru, B Snetsinger, D Good… - Leukemia Research, 2018 - Elsevier
Immune dysregulation is a common feature of myelodysplastic syndromes (MDS) and
chronic myelomonocytic leukemia (CMML), particularly in early stages. However, the genetic
basis remains poorly understood. We recently reported that macrophages from mice
deficient in tet methylcytosine dioxygenase 2 (Tet2), a model of MDS/CMML, are
hyperinflammatory and have increased expression of arginase 1 (Arg1). In macrophages
and myeloid derived suppressor cells (MDSCs) expression of Arg1 contributes to T-cell …
chronic myelomonocytic leukemia (CMML), particularly in early stages. However, the genetic
basis remains poorly understood. We recently reported that macrophages from mice
deficient in tet methylcytosine dioxygenase 2 (Tet2), a model of MDS/CMML, are
hyperinflammatory and have increased expression of arginase 1 (Arg1). In macrophages
and myeloid derived suppressor cells (MDSCs) expression of Arg1 contributes to T-cell …