[HTML][HTML] Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

A Alrubayyi, E Gea-Mallorquí, E Touizer… - Nature …, 2021 - nature.com
A Alrubayyi, E Gea-Mallorquí, E Touizer, D Hameiri-Bowen, J Kopycinski, B Charlton…
Nature Communications, 2021nature.com
There is an urgent need to understand the nature of immune responses against SARS-CoV-
2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that
the majority of PLWH with ART suppressed HIV viral load, mount a detectable adaptive
immune response to SARS-CoV-2. Humoral and SARS-CoV-2-specific T cell responses are
comparable between HIV-positive and negative subjects and persist 5-7 months following
predominately mild COVID-19 disease. T cell responses against Spike, Membrane and …
Abstract
There is an urgent need to understand the nature of immune responses against SARS-CoV-2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that the majority of PLWH with ART suppressed HIV viral load, mount a detectable adaptive immune response to SARS-CoV-2. Humoral and SARS-CoV-2-specific T cell responses are comparable between HIV-positive and negative subjects and persist 5-7 months following predominately mild COVID-19 disease. T cell responses against Spike, Membrane and Nucleoprotein are the most prominent, with SARS-CoV-2-specific CD4 T cells outnumbering CD8 T cells. We further show that the overall magnitude of SARS-CoV-2-specific T cell responses relates to the size of the naive CD4 T cell pool and the CD4:CD8 ratio in PLWH. These findings suggest that inadequate immune reconstitution on ART, could hinder immune responses to SARS-CoV-2 with implications for the individual management and vaccine effectiveness in PLWH.
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