Contribution of CCR4 and CCR8 to antigen-specific TH2 cell trafficking in allergic pulmonary inflammation
Z Mikhak, M Fukui, A Farsidjani, BD Medoff… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Recruitment of antigen-specific TH2 cells into the lung is critical for the
development of allergic airway inflammation. Although CCR4 and CCR8 are preferentially
expressed on TH2 cells and CCR4, CCR8, and CXCR3 ligands are increased in asthma,
the specific relative contribution of these receptors to antigen-specific TH2 cell trafficking into
the allergic lung is not known. OBJECTIVE: To determine the relative contribution of the
chemokine receptors CCR4, CCR8, and CXCR3 to antigen-specific TH2 cell trafficking in a …
development of allergic airway inflammation. Although CCR4 and CCR8 are preferentially
expressed on TH2 cells and CCR4, CCR8, and CXCR3 ligands are increased in asthma,
the specific relative contribution of these receptors to antigen-specific TH2 cell trafficking into
the allergic lung is not known. OBJECTIVE: To determine the relative contribution of the
chemokine receptors CCR4, CCR8, and CXCR3 to antigen-specific TH2 cell trafficking in a …