Targeting the metabolic microenvironment of tumors
KM Bailey, JW Wojtkowiak, AI Hashim… - Advances in …, 2012 - Elsevier
The observation of aerobic glycolysis by tumor cells in 1924 by Otto Warburg, and
subsequent innovation of imaging glucose uptake by tumors in patients with PET-CT, has
incited a renewed interest in the altered metabolism of tumors. As tumors grow in situ, a
fraction of it is further away from their blood supply, leading to decreased oxygen
concentrations (hypoxia), which induces the hypoxia response pathways of HIF1α, mTOR,
and UPR. In normal tissues, these responses mitigate hypoxic stress and induce …
subsequent innovation of imaging glucose uptake by tumors in patients with PET-CT, has
incited a renewed interest in the altered metabolism of tumors. As tumors grow in situ, a
fraction of it is further away from their blood supply, leading to decreased oxygen
concentrations (hypoxia), which induces the hypoxia response pathways of HIF1α, mTOR,
and UPR. In normal tissues, these responses mitigate hypoxic stress and induce …