Rates of carnitine palmitoyltransferase-catalyzed conversion of palmitoylcarnitine to
palmitoyl-CoA are markedly decreased with the progress of this reaction presumably owing
to the build up of inhibitory palmitoyl-CoA in the enzyme vicinity. High, above micellar,
concentrations of palmitoylcarnitine, phosphatidylcholine liposomes and high KCI
concentrations increased the activity, apparently by facilitating the removal of palmitoyl-CoA
from the enzyme surface. The presence of cardiolipin was found to be inhibitory. The …