Glycolytic activation of monocytes regulates the accumulation and function of neutrophils in human hepatocellular carcinoma
ZP Peng, ZZ Jiang, HF Guo, MM Zhou, YF Huang… - Journal of …, 2020 - Elsevier
Background & Aims Neutrophils are one of the most abundant components in human
hepatocellular carcinoma (HCC) and have been shown to play important roles in regulating
disease progression. However, neutrophils are very short-lived cells in circulation, and
mechanisms regulating their accumulation and functions in HCC are not yet fully
understood. Methods Monocytes were purified from non-tumor or paired tumor tissues of
patients with HCC, and their production of neutrophil-attracting chemokines was evaluated …
hepatocellular carcinoma (HCC) and have been shown to play important roles in regulating
disease progression. However, neutrophils are very short-lived cells in circulation, and
mechanisms regulating their accumulation and functions in HCC are not yet fully
understood. Methods Monocytes were purified from non-tumor or paired tumor tissues of
patients with HCC, and their production of neutrophil-attracting chemokines was evaluated …