Phase I trial of DNX-2401 for diffuse intrinsic pontine glioma newly diagnosed in pediatric patients
S Tejada, M Alonso, A Patiņo, J Fueyo… - …, 2018 - journals.lww.com
BACKGROUND There are no effective treatments for diffuse intrinsic pontine gliomas
(DIPGs); these tumors cannot be surgical resected, and diagnosis is based on magnetic
resonance imaging. As a result, tumor tissues for molecular studies and pathologic
diagnosis are infrequent. New clinical trials are investigating novel medications and
therapeutic techniques in an effort to improve treatment of patients with DIPGs. OBJECTIVE
To determine the safety, tolerability, and toxicity of an oncolytic adenovirus, DNX-2401 …
(DIPGs); these tumors cannot be surgical resected, and diagnosis is based on magnetic
resonance imaging. As a result, tumor tissues for molecular studies and pathologic
diagnosis are infrequent. New clinical trials are investigating novel medications and
therapeutic techniques in an effort to improve treatment of patients with DIPGs. OBJECTIVE
To determine the safety, tolerability, and toxicity of an oncolytic adenovirus, DNX-2401 …