Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice
S Srivastava, SD Sithu, E Vladykovskaya, P Haberzettl… - Atherosclerosis, 2011 - Elsevier
BACKGROUND: Acrolein is a dietary aldehyde that is present in high concentrations in
alcoholic beverages and foods including cheese, donuts and coffee. It is also abundant in
tobacco smoke, automobile exhaust and industrial waste and is generated in vivo during
inflammation and oxidative stress. OBJECTIVES: The goal of this study was to examine the
effects of dietary acrolein on atherosclerosis. METHODS: Eight-week-old male apoE-null
mice were gavage-fed acrolein (2.5 mg/kg/day) for 8 weeks. Atherosclerotic lesion formation …
alcoholic beverages and foods including cheese, donuts and coffee. It is also abundant in
tobacco smoke, automobile exhaust and industrial waste and is generated in vivo during
inflammation and oxidative stress. OBJECTIVES: The goal of this study was to examine the
effects of dietary acrolein on atherosclerosis. METHODS: Eight-week-old male apoE-null
mice were gavage-fed acrolein (2.5 mg/kg/day) for 8 weeks. Atherosclerotic lesion formation …
