[HTML][HTML] Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia
Y Huang, XQ Liu, SC Rall, JM Taylor… - Journal of Biological …, 1998 - ASBMB
The molecular mechanisms of hypertriglyceridemia (HTG), a common lipid metabolic
disorder in humans, often of genetic origin, are not well understood. In studying the effect of
apolipoprotein (apo) E on the metabolism of triglyceride-rich lipoproteins, we found that
expressing high plasma levels of human apoE3 in transgenic mice lacking endogenous
mouse apoE caused HTG. These transgenic animals had 3-fold higher plasma triglyceride
levels, higher very low density lipoproteins (VLDL), and lower high density lipoproteins than …
disorder in humans, often of genetic origin, are not well understood. In studying the effect of
apolipoprotein (apo) E on the metabolism of triglyceride-rich lipoproteins, we found that
expressing high plasma levels of human apoE3 in transgenic mice lacking endogenous
mouse apoE caused HTG. These transgenic animals had 3-fold higher plasma triglyceride
levels, higher very low density lipoproteins (VLDL), and lower high density lipoproteins than …