Thyroid hormone modulates the introduction of a stop codon in rat liver apolipoprotein B messenger RNA.
NO Davidson, LM Powell, SC Wallis, J Scott - Journal of Biological …, 1988 - ASBMB
Apolipoprotein B (apoB) biosynthesis by rat liver was studied following thyroid hormone (3,
5, 3′-triiodo-L-thyronine) administration to hypothyroid rats. Pharmacologic doses of 3, 5,
3′-triiodo-L-thyronine caused suppression of apoB100 synthesis but did not affect apoB48
levels. There was no detectable apoB100 synthesis in hyperthyroid rats. To examine
whether these results were mediated by the previously demonstrated mechanism of RNA
modification (Powell, LM, Wallis, SC, Pease, RJ, Edwards, YH, Knott, TJ, and Scott, J.(1987) …
5, 3′-triiodo-L-thyronine) administration to hypothyroid rats. Pharmacologic doses of 3, 5,
3′-triiodo-L-thyronine caused suppression of apoB100 synthesis but did not affect apoB48
levels. There was no detectable apoB100 synthesis in hyperthyroid rats. To examine
whether these results were mediated by the previously demonstrated mechanism of RNA
modification (Powell, LM, Wallis, SC, Pease, RJ, Edwards, YH, Knott, TJ, and Scott, J.(1987) …