[HTML][HTML] Poly (ADP-ribose) polymerase 1 represses liver X receptor-mediated ABCA1 expression and cholesterol efflux in macrophages
E Shrestha, MA Hussein, JN Savas, M Ouimet… - Journal of Biological …, 2016 - ASBMB
Liver X receptors (LXR) are oxysterol-activated nuclear receptors that play a central role in
reverse cholesterol transport through up-regulation of ATP-binding cassette transporters
(ABCA1 and ABCG1) that mediate cellular cholesterol efflux. Mouse models of
atherosclerosis exhibit reduced atherosclerosis and enhanced regression of established
plaques upon LXR activation. However, the coregulatory factors that affect LXR-dependent
gene activation in macrophages remain to be elucidated. To identify novel regulators of LXR …
reverse cholesterol transport through up-regulation of ATP-binding cassette transporters
(ABCA1 and ABCG1) that mediate cellular cholesterol efflux. Mouse models of
atherosclerosis exhibit reduced atherosclerosis and enhanced regression of established
plaques upon LXR activation. However, the coregulatory factors that affect LXR-dependent
gene activation in macrophages remain to be elucidated. To identify novel regulators of LXR …