[HTML][HTML] PARPs in lipid metabolism and related diseases

M Szántó, R Gupte, WL Kraus, P Pacher… - Progress in Lipid Research, 2021 - Elsevier
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed
light on their role in lipid metabolism. To date, PARP1, PARP2, PARP3, tankyrases, PARP9,
PARP10, PARP14 were reported to have multi-pronged connections to lipid metabolism.
The activity of PARP enzymes is fine-tuned by a set of cholesterol-based compounds as
oxidized cholesterol derivatives, steroid hormones or bile acids. In turn, PARPs modulate …